Replication evidence was compelling for CETP rs2303790 (encoding D442G; odds ratio (OR)=1.73, P=2.95 × 10−16), as well as for C6orf223 rs2295334 (A231A; OR=0.80, P=5.25 × 10−11), SLC44A4 rs12661281 (D47V; OR=1.22, P=5.13 × 10−6) and FGD6 rs10507047 (Q257R; OR=0.88, P=7.69 × 10−5), leading to genome-wide significant findings in the meta-analysis of all 6,345 AMD cases and 15,980 controls (P<5.0 × 10−8 for each of the four loci; Table 2 and Supplementary Table 2). This evidence concerns the gene CETP and age-related macular degeneration.