Data from the discovery stage analysis confirmed previously identified AMD variants in ARMS2-HTRA1 rs10490924 (P=1.20 × 10−103), CFH rs10737680 (P=7.54 × 10−38), CETP rs3764261 (P=1.66 × 10−12), ADAMTS9 rs6795735 (P=1.13 × 10−5), C2-CFB rs429608 (P=1.06 × 10−4), as well as CFI rs4698775 (P=7.5 × 10−4; Supplementary Table 1 and Supplementary Fig. 2). This evidence concerns the gene HTRA1 and age-related macular degeneration.