FTH1 and hydrops fetalis: Importantly, our data is very significant for the development of potential treatment for HF using RNA interference to induce sequence-specific post-transcriptional gene silencing of mutant FTL. Since H-ferritin homopolymers are capable of maintaining brain iron homeostasis, RNA interference could be used as a therapeutic approach even if the inhibition of the expression of the mutant allele suppresses in part (or to a high degree) the expression of the wild-type FTL allele.