One explanation for observing elevated levels of TNFα, CCL3, and CCL4 could be the range or degree that PRRs are being engaged in the Pycard-deficient mice and/or temporal and spatial dynamics of fungal cell wall PAMP engagement with PRRs in vivo that are not fully understood and further complicated by a PRR known to be engaged during infection now being absent. Here, CCL4 is linked to infection.