Anti-HSP IgG autoantibodies belong probably to the natural auto-antibodies, as they are present in healthy people, nevertheless chronic neurodegenerative process may have additional inducing effect on humoral response involving anti-HSP autoantibodies, which is reflected by significantly higher levels of anti-HSP 60 autoantibodies in PD patients compared to healthy controls. Here, HSP90B2P is linked to Parkinson disease.