We confirmed the presence of IgM and IgG autoantibodies against alpha B-crystallin in investigated group of PD patients and observed statistically significant higher levels of both IgG and IgM autoantibodies titers in parkinsonian patients compared to healthy control subjects (both at time point 1 and at time point 2) (p<0.05). The gene discussed is CD40LG; the disease is Parkinson disease.