Mice with a conditional knockout of TβRII in myeloid cells (LysM+) that were generated in our laboratory, showed a reduced suppressive function of CD11b+Gr1+ cells, increased antigen-presenting properties of dendritic cells and increased anti-tumorigenic properties of tumor associated macrophages (TAMs); and these changes were reflected in reduced tumor growth [21]. The gene discussed is TGFBR2; the disease is neoplasm.