ADAMTS19 and premature menopause: We focused first on the ovarian gene Adamts19 (a disintegrin-like and metallopeptidase [reprolysin type] with thrombospondin type 1 motif, 19), identified in a PCR-based cDNA subtraction screen, and in which polymorphisms have since been associated with premature ovarian failure (POF; [37–39].