Similarly, reducing NF-κB expression [using p65 small interfering RNAs (siRNA) to silence the p65 gene in vitro] led to significant amelioration of inflammatory signaling in cells associated with several diseases including rheumatoid arthritis [22], osteoarthritis [23], esophageal cancer [24], and myelodysplastic syndrome [25]. This evidence concerns the gene RELA and osteoarthritis.