The significance of WNT10A in organogenesis was not recognized until it was discovered that WNT10A mutations can cause Odonto-onycho-dermal Dysplasia (OODD; MIM#257980), a rare autosomal recessive syndrome characterized by sparse hair, severe tooth agenesis, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma, and hyperhidrosis (Adaimy et al. The gene discussed is WNT10A; the disease is Hyperhidrosis.