In our study, despite detecting no association with the KIF6 Trp719Arg polymorphism in either T2DM or T2DM + CHD in the overall study population, further analysis on sex-differentiated association revealed a significantly higher frequency of the 719Arg allele in the men from both the T2DM and T2DM + CHD groups (both P < 0.01). The gene discussed is KIF6; the disease is type 2 diabetes mellitus.