NOTCH3 and Stroke: Since Notch3 inactivating mutations are present in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an hereditary disease that causes stroke and dementia (101) and blockade of AngII generation helps to prevent stroke (102), it has been suggested that down-regulation of Notch could be part of the molecular mechanism by which AngII induces vascular complications (98).