NFKB1 and neoplasm: Since the NF-κB pathways in DCs are essential for its optimal functions (169, 177–179), this chimeric chaperone possesses two distinct features that are required for efficient cancer vaccine therapy: enhancing the cross-presentation of tumor antigens in the chaperone complex cargo and concurrently provoking the functional activation of DCs via engaging the NF-κB signaling (173).