ADRB2 and Familial prostate cancer: ADRB2 is assumed to be up-regulated in castration-resistant prostate cancer to support sensitization of the androgen receptor, but it is down-regulated in the androgen independent sub-line LNCaP-abl at the mRNA-level (62), and at the protein level in LNCaP-Rf (57), both compared to the parental LNCaP cell line.