PAX6 and aniridia: Previous studies demonstrated that people harboring PAX6 mutation displayed a clinical symptom spectrum including aniridia, corneal opacification, keratitis, cataract, glaucoma, lens dislocation, ciliary body hypoplasia, foveal hypoplasia, strabismus, nystagmus, Peter’s anomaly, optic nerve defects [5], hyposmia, abnormal inter-hemispheric auditory transfer [6], impaired islet function [7] and brain structure abnormalities [8].