Similarly the frequency of HLADR expressing CD4 T cells [Figure 4c] was not different between our three groups, F (2, 60) = 2.87, p = .06, η2 = .08 [Figure 4d], though we did find significant differences in the frequency of peripheral HLADR+ve CD8 T cells, F (2, 60) = 13.58, p < .001, η2 = .31 between our three groups [Figure 4d], driven by an increase in the percentage of HLADR+ve CD8 T cells in hip fracture patients with depressive symptoms compared with healthy controls (p < .001). This evidence concerns the gene CD4 and hip fracture.