Similarly, differences in the frequency of circulating CD28-ve CD8 T cells were found between the three groups, F (2, 62) = 8.30, p = .001, η2 = .21, driven by a significant increase in the percentage of CD28-ve CD8 T cells in hip fracture patients with depressive symptoms compared with healthy controls (p = .001) and hip fracture patients without depressive symptoms (p = .01) [Figure 2b]. This evidence concerns the gene CD28 and hip fracture.