IGF1 and lung cancer: Peng et al. (2013) has investigated the role of miRNAs in lung cancer focused on the IGF-1 signaling pathway as a therapeutic target. They performed a high throughput miRNA array analysis using a cohort of stage 1 adenocarcinomas and found that miR-486 was the most downregulated miRNA in lung tumors compared to adjacent uninvolved lung tissues. miR-486 was shown to bind directly to IGF-1 3′UTR decreasing IGF-1 mRNA and protein levels in NSCLC cell lines (Peng et al., 2013).