IGF1 and metabolic disease: Dysregulation of the IGF-1 signaling pathway has been implicated in a variety of aging-related diseases including muscle disease, cardiovascular diseases (CVDs), neurodegenerative diseases, metabolic diseases, and cancer (Andreassen et al., 2009; Zha and Lackner, 2010; Zemva and Schubert, 2011; O’Neill et al., 2012; Piccirillo et al., 2014).