However, this mutation generated the core sequence (CAgCTG) for the binding of Myogenin TF, which is a TF that regulates cell cycle and stem cell proliferation and was associated with various types of tumors including rhabdo-myosarcoma, liver neoplasms, soft tissues neoplasms, and neuroectodermal tumors (Figure 3A) (Wang et al., 1995; Meyer and Brinck, 1997; Kumar et al., 2000; Kobayashi et al., 2004). This evidence concerns the gene MYOG and primitive neuroectodermal tumor.