CD4 and neoplasm: The importance of the AHR in regulating autoimmunity and tumor immunity is supported by preclinical studies and analyses of human tumor tissue demonstrating that binding of the TRP metabolite kynurenine (KYN) to the AHR results in reprograming the differentiation of naïve CD4+ T-helper (Th) cells favoring a regulatory T cells phenotype (Treg) while suppressing the differentiation into interleukin-17 (IL-17)-producing Th (Th17) cells.