DCs are necessary for effective priming of the T-cell response in erythrocytic-stage malaria (26), and two subsets of splenic DCs, CD8− and CD4+ classical DCs, have been shown to present antigen for the activation of CD4+ T-cells during an erythrocytic-stage infection with P. chabaudi and P. berghei, respectively (26–29). This evidence concerns the gene CD4 and infection.