Nonetheless, it was possible to draw parallels with the original Mosmann and Coffman model; malaria researchers observed that the erythrocytic stages triggered a strong IFN-γ response during acute infections in P. berghei, P. yoelii, and P. chabaudi infections in mice, as well as in P. falciparum infection in humans (19–24). Here, IFNG is linked to malaria.