As protective CD8+ T-cells specific for a peptide of CSP from P. yoelii can be primed by dendritic cells (DCs) in lymph nodes after infection with sporozoites (16), it is likely that DCs in lymph nodes might also be critical for priming CD4+ T-cell responses to Plasmodium pre-erythrocytic stages. The gene discussed is CD8A; the disease is infection.