We and others demonstrated that J2 prostaglandins induce COX-2 up-regulation in cancer cells (Kim et al., 2008; Kitz et al., 2011) and neuronal cells (Li et al., 2004a) and this event can be driven by MAPK activation (Li et al., 2004a; Kitz et al., 2011) or Akt/AP-1 activation (Kim et al., 2008). The gene discussed is PTGS2; the disease is cancer.