Moreover, J2 prostaglandins inhibit the de-ubiquitinating enzyme UCH-L1 (Li et al., 2004b; Liu et al., 2011), which is down-regulated in AD brains; UCH-L1 down-regulation is inversely proportional to the number of neurofibrillary tangles (Choi et al., 2004). The gene discussed is UCHL1; the disease is Alzheimer disease.