Post-mortem data from depressed patients showed that depression is associated with a decrease in BDNF levels in the hippocampus and PFC, and an increase of BDNF in the NAc (Dwivedi et al., 2003; Karege et al., 2005; Krishnan et al., 2007; Sun et al., 2013). This evidence concerns the gene BDNF and depressive symptom measurement.