In 2009, the AVAiL study was very important for the approval, in Europe and the United States, of the use of bevacizumab, a monoclonal antibody against VEGF, in advanced-stage NSCLC.(14) Nevertheless, posterior analysis of these results implied discontinuation of bevacizumab in advanced NSCLC since the cost-benefit association was not confirmed as to an increase in OS (only about 2 months), according to the European Medicines Agency (EMA).(15). The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.