CLPTM1L and lung adenocarcinoma: Those that stand out are the pathways linking VEGF and the CLPTM1L (cleft lip palate transmembrane-like receptor 1).(3,28) By means of genome wide association studies (GWAS,) polymorphic variants of susceptibility to lung cancer were detected in chromosomes 5p15.33, 6p21, and 15q25.(28) Specifically, the variants rs2736100, located at intron 2 of telomerase reverse transcriptase (TERT) and rs401681 of CLPTM1L C/T, in 5p15.33, are associated with lung adenocarcinomas.