Cases with PART ‘possible’ at NFT stages IV have, again, a higher ApoE ε4 allele frequency than cases with low AD-related changes (i.e., low amyloid plaque density and NFT stage 0), and the value reaches significance if we understand the legend accompanying Table 1 of Crary et al. that states that all comparisons were made with “Braak NFT stage 0 cases” (although one value labeled as significant is in the Braak NFT stage 0 column) [8]. The gene discussed is APOE; the disease is Alzheimer disease.