Recent studies have indicated that IL-37 down-regulated the expressions of pro-inflammatory cytokines in chronic inflammatory diseases such as system lupus erythematosus (SLE) [16], rheumatoid arthritis (RA) [17] and inflammatory bowel disease [18], suggesting IL-37 might abrogate pro-inflammatory cytokines productions to reduce inflammatory responses in AS. This evidence concerns the gene IL37 and systemic lupus erythematosus.