The A allele of IL10A-592A/C was always linked with the T allele of and IL10A-819 T/C and C with C. IL10A-592A/A and IL10A-819 T/T genotypes were more frequently observed in malaria (+) compared with malaria (−) group (p < 0.001), even when adjusted by sex and age. The gene discussed is IL10; the disease is malaria.