The GOlimumab After Former anti-tumor necrosis factor α Therapy Evaluated in Rheumatoid arthritis (GO-AFTER) study (Clinicaltrials.gov NCT00299546; registered 3 March 2006) was the first and hitherto only prospective, randomized, phase 3, double-blind, placebo-controlled trial to assess a tumor necrosis factor (TNF) α inhibitor exclusively in patients with active rheumatoid arthritis (RA) who previously received TNF inhibitor(s). The gene discussed is TNF; the disease is rheumatoid arthritis.