EIF4E and ovarian carcinoma: As presented in Fig. 6, enforced expression of eIF4E partially rescues ovarian carcinoma cell from calcium inhibitors + ABT-737-induced cytotoxicity as assessed by the decrease of the percentage of sub-G1 peak (48.6 vs 31.7 % for BAPTA-AM+ABT-737 condition and 52.3 vs 41.8 % W7+ABT-737 condition) (Fig. 6d), the increase of IGROV1-R10 cell viability (43.4 vs 66.3 % for BAPTA-AM+ABT-737 condition and 47.1 vs 65.7 % W7+ABT-737 condition) (Fig. 6e), an increase in Mcl-1 expression (1.5× in average) and the reduction of Caspase 3 and PARP cleavages (Fig. 6f).