PIK3CA and neoplasm: The Broad Institute project37 undertook whole‐exome and whole‐genome sequencing in 149 tumour–normal pairs, verifying previously identified mutations in TP53, CDKN2A, SMAD4, ARID1A and PIK3CA. Previously unidentified mutations in SPG20, TLR4, ELMO1 and DOCK2 were also found, and a possible role for the RAC1 pathway (a modulator of epithelial–mesenchymal transition) was identified.