FGF2 and ischemia: Another study evaluating Fgf2−/− mice subjected to chronic coronary artery occlusion observed no difference in infarct size at their earliest time point (4 days after ischemia onset) but did observe a significantly increased infarct size in Fgf2−/− mice beginning 1 week after the onset of ischemia, which was suggested to be primarily related to the necessity of FGF2 for infarct scar contraction during late remodeling (Virag et al. 2007).