While the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) and Valsartan Antihypertensive Long‐term Use Evaluation (VALUE) studies have suggested a reduction in new onset AF with AT1 receptor blockade (Wachtell et al. 2005; Schmieder et al. 2008), other trials involving ACE inhibitors (e.g., Hansson et al. 1999a,b; Salehian et al. 2007) or ARB (e.g., Yusuf et al. 2008) have not revealed any benefit of RAAS inhibition in patients with primary hypertension. Here, AGTR1 is linked to essential hypertension.