CLCN2 and cystic fibrosis: However, WT‐ClC2 and to a lesser extent the 790 and 584 mutants were strongly expressed in the apical surface of CFBE cells (Fig. 1), confirming a targeted increase in ClCN2 can result in the colocalization of ClCN2 and ENaC in CF cells, providing increased opportunity for the direct regulation of ENaC at the apical surface.