It has been suggested by previous studies that pro-inflammatory cytokines such as IL-6, IL-8 and TNF-α can be used as peripheral HD biomarkers.47, 48 Other terms such as diabetes mellitus could also be interesting as mouse models of HD can develop diabetes mellitus,49 and it was shown that type II diabetes exhibits common features with other neurodegenerative disorders.50 Finally, we discovered enrichment of target genes of miRNAS (miR-138/218) previously reported to be downregulated in HD models. This evidence concerns the gene TNF and type 2 diabetes mellitus.