DLX2 and amyotrophic lateral sclerosis: In hippocampus, primary motor cortex and brainstem motor nuclei, the mRNAs of most putative target genes were non-significantly reduced in ALS compared to control; exceptions were a significant increase of Dlx2 in hippocampus, and a significant decrease of Socs1 in primary motor cortex and brainstem motor nuclei (p < 0.05, Figure 3).