SOD1 and early-onset autosomal dominant Alzheimer disease: As regards miR-125b, which is expressed in neurons and astrocytes and seems to be involved in the astrogliosis that occurs in Alzheimer disease [49], we found that this miRNA was significantly down-regulated in SVZ and hippocampus – areas in which differentiating NSPCs were significantly increased in G93A-SOD1 mice compared to control – but significantly up-regulated in primary motor cortex in association with reduced levels of Sox6.