GPC3 and neoplasm: In further in vivo experiments, the present study identified that tumor nodule formation in nude mice, induced by HepG2 cells, was suppressed significantly following treatment with DCs-GPC3-CIKs, indicating that specific CIKs induced by DCs-GPC3 targeting of GPC3-expressing HCC cells exhibited strong antitumor activity against HepG2 xenografts in mice.