CLOCK and neoplasm: Furthermore, upregulated expression of hClock accounted for a 61.43% increase in tumor volume and a 91.38% increase in tumor weight at day 42 post-injection compared with that of the control group (Fig. 4); the developed tumor volume and weight were 1990.0±101.4 mm3 and 2.21±0.20 g, respectively, in the hClock overexpression group, compared with 1232.7±69.2 mm3 and 1.16±0.14 g in the control group, respectively (P<0.01).