Through activating or inhibiting several downstream components of the cell death machinery, including Bcl-2-associated death promoter, caspase-9, fork-head homologue in rhabdomyosarcoma, nuclear factor-κB and p53, via phosphorylation, p-AKT regulates numerous cell activities, including cell proliferation, differentiation, apoptosis and migration (31). The gene discussed is TP53; the disease is rhabdomyosarcoma.