Specifically, Clusters C1A and C1B, comprising SDHx- and VHL-mutated tumours, respectively, display a pseudohypoxic signature, whereas Cluster C2A, corresponding to RET-, NF1- and TMEM127-mutated tumours, displays activation of the RAS/mitogen-activated protein kinase (MAPK) signaling pathway. This evidence concerns the gene WNK2 and neoplasm.