In addition, we show here that PNMT gene encoding for the enzyme catalysing the conversion of noradrenaline to adrenaline is hypermethylated and downregulated in VHL tumours, suggesting that epigenetic silencing of this gene explains the noradrenergic phenotype of both VHL- and SDHx-mutated tumours42. The gene discussed is PNMT; the disease is neoplasm.