ARHGEF12 and cancer: Other genes of interest carrying damaging variants and listed in the Cancer Gene Census included MET (activating mutation p.E355K), CDH1, ARHGEF12, SLC45A3, SMO, CARD11, MLL2, PCM1, ATRX, GNAS, FLT3 and FHIT. These genes were altered in a single tumour (Fig. 2c).