Previous studies have demonstrated that CHCHD2 is a member of a protein family that contains the (coiled coil 1)-(helix 1)-(coiled-coil 2)-(helix 2) (CHCH) domain (23); however, no previous studies have reported an interaction between CHCHD2 and HCC. The gene discussed is CHCHD2; the disease is hepatocellular carcinoma.