CDK5 and its main activators, p35 and p39 are rarely expressed in pancreatic ducts, but found to be highly expressed due to gene amplification in 67% human pancreatic ductal adenocarcinoma, and was further reported to act in concert with K-Ras to promote malignant progression, migration and invasion of pancreatic cancer cells [180,260]. The gene discussed is CDK5; the disease is familial pancreatic carcinoma.