Moreover, 33 simple coding mutations have been reported in the COSMIC database for CDK2 in a wide variety of cancer tissues, most of which are missense mutations in the Nterminal lobe (amino acid 2, 13, 20, 34, 45, 68, 84), one silent mutation at amino acid 45 and one deletion frameshift at amino acid 79 [135]. The gene discussed is CDK2; the disease is cancer.