Liu et al (22) also found that CD133+ cells in GBM were more resistant to TMZ, paclitaxel and VPl6 than the negative cells, which may be induced by the higher expression levels of breakpoint cluster region pseudogene 1 and MGMT, as well as the anti-apoptosis protein and inhibitors of apoptosis protein families in CD133+ cells. Here, PROM1 is linked to glioblastoma.