Therefore, once established, it is speculated that Ct-OATP1B3 mRNA, together with other markers and image diagnostic methods such as colonoscopy, computerized tomography, and magnetic resonance imaging, may improve the accuracy and sensitivity of current colon cancer screening, and may provide other important clinico-pathological information that ultimately contribute to reduction in the incidence of morbidity and mortality of the disease. Here, SLCO1B3 is linked to colonic neoplasm.