Only tumor size (HR, 2.462; 95% CI, 1.652–3.671; P<0.001), tumor number (HR, 1.802; 95% CI, 1.194–2.719; P=0.005), PVTT (HR, 2.075, 95% CI, 1.418–3.037; P<0.001), preoperative AFP level (HR, 1.539;95% CI, 1.027–2.305; P=0.037) and PVT1 expression (HR, 1.653; 95% CI, 1.019–2.681; P=0.042) were identified as independent prognostic factors associated with tumor recurrence following liver transplantation, as determined by the Cox multivariate analysis (Table IV). The gene discussed is AFP; the disease is neoplasm.