Various classic lncRNAs have been characterized in human hepatocarcinogenesis as having oncogenic and tumor suppressive roles, such as HOX transcript antisense RNA (HOTAIR) (10,11), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) (12), maternally expressed 3 (MEG3) (13) and H19 (14). The gene discussed is MEG3; the disease is neoplasm.