This study was spurred by our previous observation that sCD163, as well as TNFα, IL6, and CRP concentrations, increases with deteriorating glycemic control in BMI-matched groups of subjects with NGT, IGT, and T2DM (24), which is in accordance with obesity-associated WAT inflammation varying between individuals, possibly due to depot-specific differences. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.