To better understand the relationship between adiposity parameters and sCD163 and the effect of overweight/obesity and T2DM on that relationship, we evaluated the association between measures of adiposity and relative body fat distribution vs sCD163 in groups of overweight/obese men, overweight/obese T2DM men, as well as a ‘control group’ of normal-weight men. The gene discussed is CD163; the disease is obesity due to melanocortin 4 receptor deficiency.