TNF and obesity due to melanocortin 4 receptor deficiency: This relationship was strengthened by the discovery that, within WAT, inflammatory mediators such as TNFα and interleukin 6 (IL6) are predominantly derived from non-adipocytes, particularly macrophages (7, 8), and that obesity-associated WAT inflammation is characterized by an increased abundance of adipose tissue macrophages in mice (8, 9).