In this study, groups of overweight/obese non-diabetic men (overweight/obese men) and overweight/obese men with T2DM (overweight/obese T2DM men) as well as a ‘control group’ of normal-weight healthy men (normal-weight men) were included to assess the effect of overweight/obesity and T2DM on the association between adiposity parameters and sCD163. The gene discussed is CD163; the disease is obesity due to melanocortin 4 receptor deficiency.