In the case of inflammation-associated insulin resistance, there are several instances of crosstalk between insulin signaling composed of IRS1-4 proteins, PI3K, AKT/protein kinase B (PKB), and mitogen-activated protein kinases (MAPKs, i.e., p38, JNK, and IKKβ) of inflammatory signaling. The gene discussed is MAPK8; the disease is Insulin resistance.