Together, results from Figure 1A-E and Additional file 1: Figure S1 suggest that knocking-down TR4 in PCa cells, and not in macrophage THP-1 cells, led to suppress macrophage recruitment to the CM from PCa siTR4/THP-1 scr (or THP-1 siTR4) co-culture system. Here, NR2C2 is linked to posterior cortical atrophy.