Furthermore, it should be noted that we have observed a similar effect of cAMP on p53 in carcinoma and sarcoma cell lines such as MCF-7 [10], U2-OS [10], and HCT116 (unpublished results), suggesting that inhibition of the tumour suppression function of wild type p53 by cAMP is not a phenomenon restricted to BCP-ALL. Here, TP53 is linked to acute lymphoblastic leukemia.