Interesting, the expression of IκBα protein (0.588 ± 0.002 vs. 0.086 ± 0.008, P = 0.000), a negative feedback regulate of NF-κB, was also significantly increased about seven times in liver tissues of mice with FHF (Figure 5A). The gene discussed is NFKB1; the disease is TNF receptor 1-associated periodic fever syndrome.