Moderate grades are characterised by multiple small focal retinal lesions with moderate vasculitis affecting all retinal vessels evident in brightfield (Additional file 1: Figure S1G) and as Cx3cr1-GFP+ perivenular infiltrates (Additional file 1: Figure S1H) with an absence of fluorescein leakage (Additional file 1: Figure S1I). The gene discussed is CX3CR1; the disease is vasculitis.