Conversely, compared with empty vector-transfected cells, SPOCK1-transfected cells showed increased growth rates (Figure 3A) (P < 0.01), greater colony forming abilities (Figure 3B) (P < 0.001), increased DNA replication (Figure 3C), larger mean tumor volume (Figure 4B) (P < 0.05) and higher Ki-67 index (Additional file 3: Figure S2B). This evidence concerns the gene MKI67 and neoplasm.