S100A7 and neoplasm: Furthermore, with S100A7 overexpression, MDA-MB-231 cells gained mesenchymal properties (fibroblast-like cell shape and absence of cell-cell adhesion) and increased tumor growth in nude mice; in contrast, with S100A7 overexpression, MCF7 cells gained epithelial properties (flat scale-like cell shape and increased cell-cell adhesion) and showed reduced tumor growth in nude mice (Table 1).