HOXA10 and glioblastoma: This is further supported by the observation that a significant correlation between DNA methylation and expression was only observed for samples with gain of CHR7 as visualized for HOXA10. The involvement of gene dosage mediated induction of HOX-signature expression is compatible with the observation that HOX-high GBM are under-represented in G-CIMP positive GBM, which reportedly have a much lower frequency of CHR7 gain [2].