TWEAK and its receptor, fibroblast growth factor-inducible protein 14 (Fn14), have recently been implicated in tumor cell pathogenesis [13,14] and upregulation of MMP9 [15], which is generally associated with poor disease prognosis due to its ability to promote tumor growth, migration, invasion, and metastasis [16]. This evidence concerns the gene TNFRSF12A and neoplasm.